Synthesis, characterization and DNA-binding properties of Ru(II) complexes coordinated by ofloxacin as potential antitumor agents

Autor:	Dongwei Huang, Qiong Wu, Xicheng Wang, Wenjie Mei, Chengxi Wang, Chuqin Yu, Yongchang Zeng
Rok vydání:	2015
Předmět:	Cancer chemotherapy biology Chemistry Stereochemistry Spectroscopy methods Binding properties biology.organism_classification humanities HeLa chemistry.chemical_compound Materials Chemistry medicine Ofloxacin Physical and Theoretical Chemistry DNA Binding affinities medicine.drug
Zdroj:	Journal of Coordination Chemistry. 68:1489-1499
ISSN:	1029-0389 0095-8972
DOI:	10.1080/00958972.2015.1020797
Popis:	Three Ru complexes coordinated by oxfloxacin, [Ru(L)2(OFX)]Cl·2H2O (L = bpy, 1; dmbpy, 2; phen, 3; and OFX = ofloxacin), were synthesized and characterized. These complexes can inhibit the growth of cervical cancer HeLa cells efficiently. Furthermore, these three complexes exhibited excellent binding affinities with DNA, as confirmed by spectroscopy methods and viscosity experiments. Therefore, the synthesized Ru(II) complexes have excellent DNA-binding abilities with potential applications in cancer chemotherapy.
Databáze:	OpenAIRE
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