Left Bundle Branch Area Pacing for Cardiac Resynchronization Therapy
| Autor: | Óscar Cano, Marek Jastrzębski, Angela Naperkowski, Dominik Beer, Parikshit S. Sharma, Faiz A. Subsposh, Alexander R. Dal Forno, ShunmugaSundaram Ponnusamy, Sudip Nanda, Paweł Moskal, Bengt Herweg, Pugazhendhi Vijayaraman, Wilson Young, Agnieszka Bednarek |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Ejection fraction Ischemic cardiomyopathy Left bundle branch block business.industry medicine.medical_treatment Cardiac resynchronization therapy 030204 cardiovascular system & hematology medicine.disease 03 medical and health sciences QRS complex 0302 clinical medicine Internal medicine Heart failure Left bundle branch cardiovascular system Cardiology medicine In patient cardiovascular diseases 030212 general & internal medicine business |
| Zdroj: | JACC: Clinical Electrophysiology. 7:135-147 |
| ISSN: | 2405-500X |
| Popis: | Objectives The aim of this study was to assess the feasibility and outcomes of left bundle branch area pacing (LBBAP) in patients eligible for cardiac resynchronization therapy (CRT) in an international, multicenter, collaborative study. Background CRT using biventricular pacing is effective in patients with heart failure and left bundle branch block (LBBB). LBBAP has been reported as an alternative option for CRT. Methods LBBAP was attempted in patients with left ventricular ejection fraction (LVEF) Results LBBAP was attempted in 325 patients, and CRT was successfully achieved in 277 (85%) (mean age 71 ± 12 years, 35% women, ischemic cardiomyopathy in 44%). QRS configuration at baseline was LBBB in 39% and non-LBBB in 46%. Procedure and fluoroscopy duration were 105 ± 54 and 19 ± 15 min, respectively. LBBAP threshold and R-wave amplitudes were 0.6 ± 0.3 V at 0.5 ms and 10.6 ± 6 mV at implantation and remained stable during mean follow-up of 6 ± 5 months. LBBAP resulted in significant QRS narrowing from 152 ± 32 to 137 ± 22 ms (p Conclusions LBBAP is feasible and safe and provides an alternative option for CRT. LBBAP provides remarkably low and stable pacing thresholds and was associated with improved clinical and echocardiographic outcomes. |
| Databáze: | OpenAIRE |
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