Influence of non-surgical periodontal therapy on insulin resistance in chronic periodontitis subjects with prediabetes

Autor: Pratibha Gopalkrishna, Rupali Agnihotri, Shravani Babladi, Shobha U. Kamath, Sushma Jogi, Brunda Arun
Rok vydání: 2018
Předmět:
Zdroj: International Journal of Diabetes in Developing Countries. 39:273-283
ISSN: 1998-3832
0973-3930
DOI: 10.1007/s13410-018-0682-6
Popis: Prediabetes (PRD) has been closely associated with chronic periodontitis (CP). Lately, studies have proposed the role of glutathione peroxidase (GPx), a ubiquitous antioxidant, in potentiating insulin resistance (IR), a significant factor in PRD. As overexpression of GPx is associated with CP as well as IR, the current study was undertaken to evaluate the influence of non-surgical periodontal therapy (NSPT) on GPx levels and hence the IR in CP subjects with PRD. Forty-seven subjects were divided into two major groups: healthy controls (n = 11) and CP (n = 36), according to probing depth (PD) and clinical attachment loss (CAL). The CP patients were subdivided into CP only (n = 18) and CP with PRD (n = 18) based on baseline FBS levels. Serum and crevicular GPx and malondialdehyde (MDA) were measured in all the subjects using spectrophotometry. The participants underwent NSPT at baseline and 3 months. At 6 months, all the parameters were re-recorded. At 6 months after NSPT, there was significant improvement in periodontal health (p
Databáze: OpenAIRE
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