Systemische Karyomegalie mit chronischer interstitieller Nephritis

Autor:	A. Schmassmann, M. J. Mihatsch, M. Spöndlin, Holger Moch
Rok vydání:	1994
Předmět:	Pathology medicine.medical_specialty business.industry Interstitial nephritis Rectum medicine.disease Pathology and Forensic Medicine Transplantation Pathogenesis Karyomegaly medicine.anatomical_structure Shock (circulatory) medicine Etiology Adenocarcinoma medicine.symptom business
Zdroj:	Der Pathologe. 15:44-48
ISSN:	1432-1963 0172-8113
DOI:	10.1007/s002920050024
Popis:	Systemic karyomegaly associated with interstitial nephritis was first described in 1978 by Mihatsch. Seven cases have been reported to date. We give an account of an autopsy case of systemic karyomegaly in a 30-year-old Italian man. Bizarre enlargement of nuclei was found in renal tubular epithelial cells, Schwann cells and in smooth muscle cells of vessels and bowel and, less obviously, in endothelial and adventitial cells of vessels, in alveolar epithelial cells and in astrocytes of the brain. These findings were associated with chronic interstitial nephritis, nonspecific hepatopathy, adenocarcinoma of the rectum and multiple slerosis. The clinical course was marked by chronic renal failure, chronic haemodialysis and renal transplantation. The patient died 8 years after diagnosis in septic-toxic shock. The aetiology and pathogenesis of the disease are discussed.
Databáze:	OpenAIRE
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