Angiogenesis in chronic myeloproliferative diseases detected by CD34 expression
| Autor: | M. Bai, N. Zagorianakou, Bourantas Kl, A. Katsaraki, Niki J. Agnantis, K. Panteli |
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| Rok vydání: | 2004 |
| Předmět: |
Pathology
medicine.medical_specialty Myeloid medicine.diagnostic_test business.industry Essential thrombocythemia Angiogenesis CD34 Hematology General Medicine medicine.disease medicine.anatomical_structure Polycythemia vera hemic and lymphatic diseases Biopsy Medicine Bone marrow business Myelofibrosis |
| Zdroj: | European Journal of Haematology. 72:410-415 |
| ISSN: | 0902-4441 |
| DOI: | 10.1111/j.1600-0609.2004.00235.x |
| Popis: | Increased bone marrow angiogenesis estimated as bone marrow microvessel density (MVD), or as serum angiogenic factor levels and/or immunohistochemical expression of these factors in bone marrow biopsy has been demonstrated in a variety of hematological disorders including chronic myeloproliferative diseases (MPDs). The aim of this study was to investigate the MVD in 25 cases of myelofibrosis with myeloid metaplasia (MMM). MVD was estimated by CD34 immunohistochemical expression in bone marrow biopsies. A control group of 27 patients without bone marrow disease, eight cases of polycythemia vera (PV), 41 cases of essential thrombocythemia (ET) and nine cases of chronic myeloid leukemia (CML) were also studied. Moreover, in cases with MMM, MVD was correlated with clinical, laboratory, histological parameters and the outcome of the patients. Our study confirmed a significantly higher degree of angiogenesis in MMM, PV, ET and CML compared with controls (P |
| Databáze: | OpenAIRE |
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