HDNC (1-hydroxy-5, 7-dimethoxy-2 naphthalene-carboxaldehyde) for rapid recovery of gastric damage in incision wound model of rats
| Autor: | Ila Shukla, Padam Kant, Ch V Rao, Shyam Sundar Gupta, Shravan Kumar Paswan, Lubna Azmi |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Wound strength Incision wound Stomach Pharmacology Breaking strength Bioactive compound Surgery 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology medicine.anatomical_structure chemistry medicine Duodenum Wound healing Healing wounds |
| Zdroj: | Wound Medicine. 18:47-51 |
| ISSN: | 2213-9095 |
| DOI: | 10.1016/j.wndm.2017.06.002 |
| Popis: | HDNC (1-hydroxy-5, 7-dimethoxy-2 naphthalene-carboxaldehyde) is a bioactive compound derived from Aegle marmelos (Rutaceae, ‘Bael’). The current study was conducted to conclude the effect of HDNC on mechanical properties and collagen content of stomach and duodenal wounds in rats. This experiment included wound creation in rumen (non-glandular part) & corpus (oxyntic) part of stomach and duodenum. These wounds were analyzed after 0, 5, 15 & 30 days post-operation. HDNC treatment found to improve the mechanical strength of healing wounds of stomach and duodenum. Breaking strength and breaking energy were also augmented in presence of HDNC. Healing process was slower in initial post-operative phase (after 5 days). However in later days wound strength enhanced drastically. Direct relation was observed between total collagen content and mechanical strength. These findings point towards that the amplification of mechanical strength and collagen content in wounds has been the outcome of HDNC treatment. |
| Databáze: | OpenAIRE |
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