Tumor microenvironment responsive biomimetic copper peroxide nanoreactors for drug delivery and enhanced chemodynamic therapy
| Autor: | Xinyi Li, Yi Lu, Yongqiong Wu, Zhigang Xu, Yong-E Gao, Shengxin Hou, Peng Xue, Xianbin Ma, Jiaqi Cheng, Mingming Guo, Yuejun Kang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
inorganic chemicals
Tumor microenvironment Biocompatibility General Chemical Engineering 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Sericin Industrial and Manufacturing Engineering 0104 chemical sciences chemistry.chemical_compound chemistry Apoptosis Drug delivery Cancer research medicine Environmental Chemistry Hydroxyl radical Doxorubicin 0210 nano-technology Hydrogen peroxide medicine.drug |
| Zdroj: | Chemical Engineering Journal. 416:129037 |
| ISSN: | 1385-8947 |
| DOI: | 10.1016/j.cej.2021.129037 |
| Popis: | Facing the multiple and arduous characteristics of tumors, chemodynamic therapy (CDT) is an emerging therapeutic approach. It uses toxic hydroxyl radical (∙OH) produced by Fenton reaction to induce cell apoptosis, which is not restricted by other factors such as the limitations of tissue depth and hypoxic tumor microenvironment. However, the problem of insufficient endogenous hydrogen peroxide (H2O2) seriously restricts its development and widespread use. In this study we developed a new type of nano-Fenton catalyst SS-CuO2@Dox (SCD), which was prepared by the peroxidation reaction of Cu2+. Under the decoration of sericin, it had excellent hydrophilicity and biocompatibility, and could target the tumor regions via the enhanced permeability and retention (EPR) effect. It could be decomposed under the acidic conditions of the tumor microenvironment (TME) and endogenously released H2O2 and Cu2+, which enhanced the efficiency of the Fenton reaction. At the same time, the successful delivery of doxorubicin (Dox), a chemotherapeutic drug, realized the combination of chemotherapy and CDT, improving the therapeutic effect of tumor. The strategy of generating H2O2 in situ could solve the problem of insufficient H2O2 in tumor without causing damage to other tissues and organs. This treatment provided a new idea for enhanced CDT and synergistic therapy, showing a promising prospect of application. |
| Databáze: | OpenAIRE |
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