Rational treatment of chemotherapy-induced peripheral neuropathy with capsaicin 8% patch: from pain relief towards disease modification
| Autor: | Kalnisha Naidoo, Enas Elsafa, Harpreet Wasan, Peter Misra, Praveen Anand, Philippe Donatien, Yiangos Yiangou, Amin Rahemtulla, Laura M. Kenny, Rosario Privitera, Hani Gabra |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.diagnostic_test
business.industry Chronic pain TRPV1 medicine.disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Anesthesiology and Pain Medicine medicine.anatomical_structure Peripheral neuropathy chemistry Chemotherapy-induced peripheral neuropathy 030202 anesthesiology Capsaicin Anesthesia Neuropathic pain Skin biopsy medicine business 030217 neurology & neurosurgery Sensory nerve |
| Zdroj: | Journal of Pain Research. 12:2039-2052 |
| ISSN: | 1178-7090 |
| Popis: | Purpose Chemotherapy-induced peripheral neuropathy (CIPN) with associated chronic pain is a common and disabling condition. Current treatments for neuropathic pain in CIPN are largely ineffective, with unfavorable side-effects. The capsaicin 8% patch (capsaicin 179 mg patch) is approved for the treatment of neuropathic pain: a single topical cutaneous application can produce effective pain relief for up to 12 weeks. We assessed the therapeutic potential of capsaicin 8% patch in patients with painful CIPN, and its mechanism of action. Patients and methods 16 patients with chronic painful CIPN (mean duration 2.5 years), in remission for cancer and not receiving chemotherapy, were treated with 30 min application of capsaicin 8% patch to the feet. Symptoms were monitored using the 11-point numerical pain rating scale (NPRS), and questionnaires. Investigations were performed at baseline and three months after patch application, including skin biopsies with a range of markers, and quantitative sensory testing (QST). Results Patients reported significant reduction in spontaneous pain (mean NPRS: -1.27; 95% CI 0.2409 to 2.301; p=0.02), touch-evoked pain (-1.823; p=0.03) and cold-evoked pain (-1.456; p=0.03). Short-Form McGill questionnaire showed a reduction in neuropathic (p=0.0007), continuous (p=0.01) and overall pain (p=0.004); Patient Global Impression of Change showed improvement (p=0.001). Baseline skin biopsies showed loss of intra-epidermal nerve fibers (IENF), and also of sub-epidermal nerve fibers quantified by image analysis. Post-patch application skin biopsies showed a significant increase towards normalization of intra-epidermal and sub-epidermal nerve fibers (for IENF: structural marker PGP9.5, p=0.009; heat receptor TRPV1, p=0.027; regenerating nerve marker GAP43, p=0.04). Epidermal levels of Nerve Growth Factor (NGF), Neurotrophin-3 (NT-3), and Langerhans cells were also normalized. QST remained unchanged and there were no systemic side-effects, as in previous studies. Conclusion Capsaicin 8% patch provides significant pain relief in CIPN, and may lead to regeneration and restoration of sensory nerve fibers ie, disease modification. |
| Databáze: | OpenAIRE |
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