ChemInform Abstract: N-(Indol-3-ylglyoxylyl)piperidines: High Affinity Agonists of Human GABA-A Receptors Containing the α1 Subunit

Autor:	Ian Collins, Ruth M. McKernan, Sally-Anne Thompson, K Quirk, Michael Rowley, William B Davey, Keith A. Wafford, Frances A. Bromidge
Rok vydání:	2000
Předmět:	Chemistry GABAA receptor Stereochemistry Benzodiazepine binding Chiral ligand General Medicine Enantiomer Receptor Selectivity α1 subunit
Zdroj:	ChemInform. 31
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200039131
Popis:	A new class of N-(indol-3-ylglyoxylyl)piperidines are high affinity agonists at the benzodiazepine binding site of human GABA-A receptor ion-channels, with modest selectivity for receptors containing the α1 subunit over α2 and α3. All three receptor subtypes discriminate substantially between the two enantiomers of the chiral ligand 10.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8d8dff2280f3c191a82ed47c997a8a47 https://doi.org/10.1002/chin.200039131 Zobrazit plný text záznamu Plný text