Cytolethal Distending Toxin: A Unique Variation on the AB Toxin Paradigm

Autor:	Joseph M. DiRienzo
Rok vydání:	2014
Předmět:	Subfamily Gram-negative bacteria biology Biochemistry Cytolethal distending toxin Cytolethal distending toxin A Protein subunit AB toxin Cytotoxic T cell General Medicine biology.organism_classification Bacteria Microbiology
Zdroj:	New Journal of Science. 2014:1-26
ISSN:	2090-8520 2356-7740
DOI:	10.1155/2014/249056
Popis:	Some of the most potent toxins produced by plants and bacteria are members of a large family known as the AB toxins. AB toxins are generally characterized by a heterogenous complex consisting of two protein chains arranged in various monomeric or polymeric configurations. The newest class within this superfamily is the cytolethal distending toxin (Cdt). The Cdt is represented by a subfamily of toxins produced by a group of taxonomically distinct Gram negative bacteria. Members of this subfamily have a related AB-type chain or subunit configuration and properties distinctive to the AB paradigm. In this review, the unique structural and cytotoxic properties of the Cdt subfamily, target cell specificities, intoxication pathway, modes of action, and relationship to the AB toxin superfamily are compared and contrasted.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8d86c9d8e202b9e870364e78c221eaf4 https://doi.org/10.1155/2014/249056 Zobrazit plný text záznamu Plný text