A simple synthesis of symmetrical α-diones from organometallic reagents and 1,4-dimethyl-piperazine-2,3-dione

Autor:	Ulrich T. Mueller-Westerhoff, Ming Zhou
Rok vydání:	1993
Předmět:	Diketone Organic Chemistry Ethylenediamine Biochemistry Medicinal chemistry chemistry.chemical_compound Piperazine chemistry Reagent Drug Discovery Lactam Organic chemistry Diethyl ether Diethyl oxalate
Zdroj:	Tetrahedron Letters. 34:571-574
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)61622-2
Popis:	Short reflux of an equimolar mixture of N-N′-dimethyl ethylenediamine and diethyl oxalate in i-propanol or diethyl ether leads to 1,4-dimethyl-piperazine-2,3-dione, which is able to react with two equivalent of organolithium or Grignard compounds to form symmetrically substituted α-diones in excellent yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8d86108b7d4daf828cab628d31f022c7 https://doi.org/10.1016/s0040-4039(00)61622-2 Zobrazit plný text záznamu