ChemInform Abstract: Self-Assembly of Disorazole C1Through a One-Pot Alkyne Metathesis Homodimerization Strategy
Autor: | H. Clinton Ramstadius, Alison N. Hulme, Helen S. Niblock, Richard C. Brewster, Kevin Ralston |
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Rok vydání: | 2015 |
Předmět: | |
Zdroj: | ChemInform. 46 |
ISSN: | 0931-7597 |
Popis: | Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C2-symmetric marine-derived bis(lactone) disorazole C1, a highly convergent, modular strategy is employed featuring cyclization through an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process. |
Databáze: | OpenAIRE |
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