ChemInform Abstract: Self-Assembly of Disorazole C1Through a One-Pot Alkyne Metathesis Homodimerization Strategy

Autor:	H. Clinton Ramstadius, Alison N. Hulme, Helen S. Niblock, Richard C. Brewster, Kevin Ralston
Rok vydání:	2015
Předmět:	chemistry.chemical_classification Chemistry Alkyne metathesis Salt metathesis reaction Disorazole C1 Alkyne General Medicine Self-assembly Metathesis Combinatorial chemistry
Zdroj:	ChemInform. 46
ISSN:	0931-7597
Popis:	Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C2-symmetric marine-derived bis(lactone) disorazole C1, a highly convergent, modular strategy is employed featuring cyclization through an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8d860d0b522aa436debb7a7a671b3a32 https://doi.org/10.1002/chin.201542211 Zobrazit plný text záznamu Plný text