Platelet transfusion does not improve outcomes in patients with brain injury on antiplatelet therapy
| Autor: | Seth R. Holland, Elizabeth Acquista, Nathaniel Gamsky, Henry R. Moore, Julie Dunn, Babak Sarani, Michael Metzler, Matthew M. Carrick, Richard Amdur, Jeremy L. Holzmacher, Heather Hancock, Mayur B. Patel, Cassandra Reynolds, Patrick Maluso |
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| Rok vydání: | 2018 |
| Předmět: |
Aspirin
business.industry Traumatic brain injury Platelet dysfunction Neuroscience (miscellaneous) 030208 emergency & critical care medicine Clopidogrel medicine.disease 03 medical and health sciences 0302 clinical medicine Platelet transfusion Anesthesia Closed head injury Developmental and Educational Psychology medicine Injury Severity Score Platelet Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Brain Injury. 32:325-330 |
| ISSN: | 1362-301X 0269-9052 |
| Popis: | Introduction: Platelet dysfunction following traumatic brain injury (TBI) is associated with worse outcomes. The efficacy of platelet transfusion to reverse antiplatelet medication (APM) remains unknown. Thrombelastography platelet mapping (TEG-PM) assesses platelet function. We hypothesize that platelet transfusion can reverse the effects of APM but does not improve outcomes following TBI.Methods: An observational study at six US trauma centres was performed. Adult patients on APM with CT evident TBI after blunt injury were enrolled. Demographics, brain CT and TEG-PM results before/after platelet transfusion, length of stay (LOS), and injury severity score (ISS) were abstracted.Results: Sixty six patients were enrolled (89% aspirin, 50% clopidogrel, 23% dual APM) with 23 patients undergoing platelet transfusion. Transfused patients had significantly higher ISS and admission CT scores. Platelet transfusion significantly reduced platelet inhibition due to aspirin (76.0 ± 30.2% to 52.7 ± 31.5%, p |
| Databáze: | OpenAIRE |
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