Controlled-Release Matrix of Acetaminophen-Ethylcellulose Solid Dispersion

Autor:	Malavé A, Hernández Ji, E. S. Ghal, Marti A
Rok vydání:	1994
Předmět:	Pharmacology Active ingredient Chemistry Stereochemistry Organic Chemistry Pharmaceutical Science Controlled release Diluent Dosage form Solvent chemistry.chemical_compound Drug Discovery Magnesium stearate Dispersion (chemistry) Dissolution Nuclear chemistry
Zdroj:	Drug Development and Industrial Pharmacy. 20:1253-1265
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639049409038365
Popis:	In this study ethylcellulose was evaluated as a carrier for preparation of prolonged release acetaminophen tablets. Solid dispersions containing three levels of ethylcellulose and acetaminophen (1:3; 1:1; 3:1) were prepared by the solvent method. Also physical mixtures at the same level of ethylcellulose and acetaminophen were prepared. Systems composed of solid dispersion or physical mixture containing the equivalent weight of 50 mg acetaminophen, Lactose fast-flo as diluent and 1% magnesium stearate as lubricant were compressed into tablets and tested for dissolution. The dissolution data showed that the drug release decreased as the level of ethylcellulose increased in the solid dispersion formulations. The drug release from tablets prepared with solid dispersion followed the diffusion controlled model for inert porous matrix, while the drug release from tablets prepared with physical mixture followed the first-order kinetic model.
Databáze:	OpenAIRE
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