Prognostic role of adjuvant radiotherapy in triple-negative breast cancer: A historical cohort study
| Autor: | Soo-Chin Lee, Wen-long Nei, Ern Yu Tan, Patrick Wai Keong Chan, Jean-Philippe Pignol, Ava Kwong, Helena M. Verkooijen, Benita Tan, Cheng Har Yip, Fuh-Yong Wong, Rebecca Dent, Mikael Hartman, Nur Aishah Taib, Nirmala Bhoo-Pathy, Gwo Fuang Ho |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty education.field_of_study Relative survival Anthracycline business.industry medicine.medical_treatment Lumpectomy Population medicine.disease Radiation therapy Breast cancer Internal medicine parasitic diseases Medicine business education Mastectomy Triple-negative breast cancer |
| Zdroj: | International Journal of Cancer. 137:2504-2512 |
| ISSN: | 0020-7136 |
| DOI: | 10.1002/ijc.29617 |
| Popis: | The value of adjuvant radiotherapy in triple-negative breast cancer (TNBC) is currently debated. We assessed the association between adjuvant radiotherapy and survival in a large cohort of Asian women with TNBC. Women diagnosed with TNBC from 2006 to 2011 in five Asian centers (N=1,138) were included. Survival between patients receiving mastectomy only, breast-conserving therapy (BCT, lumpectomy and adjuvant radiotherapy) and mastectomy with radiotherapy were compared, and adjusted for demography, tumor characteristics and chemotherapy types. Median age at diagnosis was 53 years (range: 2396 years). Median tumor size at diagnosis was 2.5 cm and most patients had lymph node-negative disease. The majority of patients received adjuvant chemotherapy (n=861, 76%) comprising predominantly anthracycline-based regimes. In 775 women with T1-2, N0-1, M0 TNBCs, 5-year relative survival ratio (RSR) was highest in patients undergoing mastectomy only (94.7%, 95% CI: 88.8-98.8%), followed by BCT (90.8%, 95% CI: 85.0-94.7%), and mastectomy with radiotherapy (82.3%, 95% CI: 73.4-88.1%). The adjusted risks of mortality between the three groups were not significantly different. In 363 patients with T3-4, N2-3, M0 TNBCs, BCT was associated with highest 5-year RSR (94.1%, 95% CI: 81.3-99.4%), followed by mastectomy with radiotherapy (62.7%, 95% CI: 54.3-70.1%), and mastectomy only (58.6%, 95% CI: 43.5-71.6%). Following multivariable adjustment, BCT and mastectomy with radiotherapy remained significantly associated with lower mortality risk compared to mastectomy only. Overall, adjuvant radiotherapy was associated with higher survival in women aged |
| Databáze: | OpenAIRE |
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