Differences in Cerebral Angioarchitectonics in Alzheimer's Disease in Comparison with Other Neurodegenerative and Ischemic Lesions
| Autor: | Ivan V. Maksimovich |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cerebral atrophy Pathology medicine.medical_specialty Binswanger Disease biology Amyloid beta business.industry Neurodegeneration Cerebral hypoxia medicine.disease Angiopathy 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Cerebral atherosclerosis medicine biology.protein Dementia business 030217 neurology & neurosurgery |
| Zdroj: | World Journal of Neuroscience. :454-469 |
| ISSN: | 2162-2019 2162-2000 |
| Popis: | Introduction: The research focuses on the clinical study of cerebral angioarchitectonics and microcirculation disorders in the development of Alzheimer’s disease (AD) in comparison with other neurodegenerative and ischemic lesions. Materials and methods: 1117 patients with different types and stages of neurodegenerative and ischemic lesions were examined, 93 of whom (8.33%) had different stages of AD—Test Group; 1024 (91.67%) had cerebral atherosclerosis, Binswanger disease (BD), vascular Parkinsonism (VP)—Control Group. The examination included definition of CDR, MMSE, cerebral CT, MRI, cerebral sciagraphy (SG), rheoencephalography (REG), morphometric detection of AD stages with TDR, and cerebral multi-gated angiography (MUGA). Results: In all patients with AD, regardless of the disease stage, specific сerebral small vessel disease (CSVD), manifested by dyscirculatory angiopathy of Alzheimer’s type (DAAT), was detected in the temporal and fronto-parietal areas. Conclusions: DAAT is an AD-specific lesion of cerebral microvessels that changes hemodynamics, causes cerebral hypoxia, and contributes to impaired amyloid beta metabolism. The combination of deposition of amyloid beta in the cerebral tissue and vascular wall, as well as specific disorders of microcirculation, cause neurodegeneration and AD development. Patients with other neurodegenerative and ischemic lesions had no DAAT manifestations. |
| Databáze: | OpenAIRE |
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