Acute myeloid leukaemia with giant granules: association with t(10; 11)(p13; q14) and disseminated intravascular coagulation

Autor:	L.M. Ching, S. K. Ma, Y.M. Yeung, Thomas S.K. Wan, Sze-Fai Yip, Twh Shek
Rok vydání:	2000
Předmět:	Disseminated intravascular coagulation medicine.medical_specialty Pathology medicine.diagnostic_test Genetic heterogeneity Cytogenetics Chromosomal translocation Karyotype Hematology Biology medicine.disease Bone marrow examination Leukemia hemic and lymphatic diseases medicine Coagulopathy
Zdroj:	Clinical & Laboratory Haematology. 22:303-305
ISSN:	0141-9854
DOI:	10.1046/j.1365-2257.2000.00329.x
Popis:	A 16-year-old Chinese girl presented with AML-M5a. A bone marrow examination showed that the myeloblasts which were overwhelming the marrow contained giant granules (pseudo-Chediak-Higashi anomaly). Her karyotype showed a rare translocation t(10; 11)(p13; q14). Molecular delineation of the translocation breakpoints was not possible. Nonetheless, this case further demonstrates the morphological and phenotypic heterogeneity of acute leukaemia with this translocation. In this girl it was associated with disseminated intravascular coagulation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8d5a6f88e3b97ea814335865c289487a https://doi.org/10.1046/j.1365-2257.2000.00329.x Zobrazit plný text záznamu Plný text ve formátu PDF