A novel spirocyclic triterpenoid and a new taraxerane triterpenoid from Teucrium viscidum
| Autor: | Feng-Ming Qi, Qiao-Ling Hu, Zheng-Yu Li, Dong-Qing Fei, Zhan-Xin Zhang, Ying-Hong Liu, Zhi Dejuan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Teucrium viscidum 010404 medicinal & biomolecular chemistry Triterpenoid Triterpene chemistry 010405 organic chemistry Stereochemistry Organic Chemistry Organic chemistry 01 natural sciences Two-dimensional nuclear magnetic resonance spectroscopy 0104 chemical sciences |
| Zdroj: | Organic Chemistry Frontiers. 4:42-46 |
| ISSN: | 2052-4129 |
| DOI: | 10.1039/c6qo00460a |
| Popis: | Two new triterpenoids, teuviscins A (1) and B (2), were isolated from the whole plants of Teucrium viscidum. Compound 1 possessed a rare 7(8→9)abeo-9R-D:C-friedo-B′:A′-neo-gammacerane skeleton, and compound 2 is a taraxerane triterpene acid. Their structures were characterized by extensive spectroscopic methods (HR-ESI-MS, 1D and 2D NMR), and the absolute configurations of 1 and 2 were secured by single-crystal X-ray diffraction analyses using Cu Kα radiation. Compound 2 showed anti-AD bioactivity which delayed animals paralysis of transgenic AD Caenorhabditis elegans. |
| Databáze: | OpenAIRE |
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