Pharmacological nNOS inhibition modified small-conductance Ca2+-activated K+ channel without altering Ca2+ dynamics
Autor: | Taro Koya, Masaya Watanabe, Hiroyuki Natsui, Takahide Kadosaka, Takuya Koizumi, Motoki Nakao, Hikaru Hagiwara, Rui Kamada, Taro Temma, Toshihisa Anzai |
---|---|
Rok vydání: | 2022 |
Předmět: | |
Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 323:H869-H878 |
ISSN: | 1522-1539 0363-6135 |
Popis: | We demonstrated that pharmacological nNOS inhibition increased the atrial arrhythmia inducibility and a specific small-conductance Ca2+-activated K+ channel blocker, apamin, reversed the enhanced atrial arrhythmia inducibility. Apamin mitigated APD abbreviation without alteration of Ca2+ transient, implying an underlying mechanism of posttranslational modification of SK channels. |
Databáze: | OpenAIRE |
Externí odkaz: |