| Autor: |
Jacqueline Libman, Abraham Shanzer, S D Lytton, B. Mester, Z. Ioav Cabantchik, M Loyevsky |
| Rok vydání: |
1994 |
| Předmět: |
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| Zdroj: |
Advances in Experimental Medicine and Biology ISBN: 9781461360902 |
| DOI: |
10.1007/978-1-4615-2554-7_40 |
| Popis: |
All organisms need to acquire iron in a bioavailable form and integrate it into biologically active molecules1. Microorganisms and plants have developed elaborate mechanisms for the synthesis, secretion and uptake of siderophores whose task is to sequester extracellular iron and mobilize it into cells as iron-complexes by receptor and translocation-mediated processes2. Mammalian cells have devised analogously regulated paths for obtaining iron from body fluids by receptor-mediated endocytosis of circulating iron-transferrin3 and possibly also by other membrane associated transport mechanisms4,5. The fate of the acquired iron depends on the metabolic status of cells and the route of entry and delivery of the metal into cell compartments. In higher organisms, regulation of cytosolic iron comprises primarily complementary mechanisms for the translational control of synthesis of proteins involved in iron intake and those involved in cellular iron storage6. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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