Quantification methods of amorphous/crystalline fractions in high-energy ball milled pharmaceutical products

Autor:	Giovanna Bruni, Alessandro Girella, Franco Sartor, Vittorio Berbenni, Chiara Milanese, Dionigio Franchi, Amedeo Marini
Rok vydání:	2011
Předmět:	Crystal Crystallography Colloid Materials science Chemical engineering Microscopy Nanoparticle Microemulsion Soft matter Physical and Theoretical Chemistry Condensed Matter Physics Penetration depth Amorphous solid
Zdroj:	Journal of Thermal Analysis and Calorimetry. 108:235-241
ISSN:	1572-8943 1388-6150
DOI:	10.1007/s10973-011-1504-y
Popis:	In this work, thermoanalytical, diffractometry, and microscopy measurements have been performed in order to characterize the effect of high energy milling on a drug active in the migraine prophylaxis and smoke cessation. We can assert that the mechanical treatment induces only a partial amorphisation of the solid phase, in particular it reduces the crystal order by producing lattice defects which propagate from the surface to the bulk crystal. For this reason, the DSC is able to detect the presence of ordered solid, while the powder X-ray diffractometry, because of its low penetration depth, does not reach the crystalline core of the particles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8d501b8c3ce3002341ef945c04c9408b https://doi.org/10.1007/s10973-011-1504-y Zobrazit plný text záznamu Full text from SpringerLink