ChemInform Abstract: Novel Anthelmintic Metabolites from an Aspergillus Species; the Aspergillimides

Autor:	B. R. Manger, Christopher Reading, Simon Edward Blanchflower, Jeremy R. Everett, Rhona Mary Banks
Rok vydání:	2010
Předmět:	Aspergillus species Aspergillus biology Strain (chemistry) Stereochemistry Chemistry General Medicine Fungus biology.organism_classification Ring (chemistry) medicine Paraherquamide Fermentation Anthelmintic medicine.drug
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
Popis:	Two members of a novel class of anthelmintics, the aspergillimides, have been isolated from the Aspergillus strain IMI 337664. This novel fungus also produced two known and one structurally novel paraherquamide. This paper describes the fermentation, isolation, structure elucidation and anthelmintic activity of aspergillimide (VM55598, 1), 16-keto aspergillimide (SB202327, 2), and the paraherquamides VM54159 (3), SB203105 (4) and SB200437 (5). The aspergillimides are equivalent to paraherquamides which have lost both the dioxygenated 7-membered ring and the phenyl ring to which this is fused; gaining in their place a C8-keto group. SB203105 is the first example of a 4-substituted paraherquamide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8d4882a281783c13154612330839aef2 https://doi.org/10.1002/chin.199809216 Zobrazit plný text záznamu Plný text