A Beta Strain-Based Spike Glycoprotein Vaccine Candidate Induces Broad Neutralization and Protection against SARS-CoV-2 Variants of Concern

Autor: Lei Cao, Jinyuan Guo, Hai Li, Hu Ren, Kang Xiao, Yan Zhang, Shuangli Zhu, Yang Song, Weijia Zhao, Dan Wu, Zhihui Chen, Yanan Zhang, Baicheng Xia, Tianjiao Ji, Dongmei Yan, Dongyan Wang, Qian Yang, Yangzi Zhou, Xiaolei Li, Zhanjun Hou, Wenbo Xu
Rok vydání: 2023
Předmět:
Zdroj: Microbiology Spectrum. 11
ISSN: 2165-0497
DOI: 10.1128/spectrum.02687-22
Popis: Continuous emergence of adaptive mutations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to challenge the use and development of existing vaccines and drugs. The value of variant-based vaccines that are capable of inducing a higher and broader protection immune response against SARS-CoV-2 variants is currently being evaluated.
Databáze: OpenAIRE