Hyperosmolar hyperglycemic coma in an infant with neonatal diabetes mellitus
| Autor: | Erin B. Henkel, Kristen Moryan-Blanchard, Zachary C. Foughty, Claire Gahm |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Type 1 diabetes
medicine.medical_specialty endocrine system diseases Diabetic ketoacidosis business.industry Insulin medicine.medical_treatment nutritional and metabolic diseases General Medicine Emergency department medicine.disease humanities Neonatal diabetes mellitus Internal medicine Diabetes mellitus Emergency Medicine medicine business Hyperglycemic Hyperosmolar Nonketotic Coma Rare disease |
| Zdroj: | The American Journal of Emergency Medicine. 54:327.e5-327.e6 |
| ISSN: | 0735-6757 |
| DOI: | 10.1016/j.ajem.2021.10.026 |
| Popis: | Neonatal diabetes mellitus (NDM) is a rare disease distinct from type 1 diabetes mellitus (T1DM). While T1DM results from autoimmune destruction of pancreatic beta cells, NDM arises from genetic mutations to insulin production and secretion pathways. We present a case of an infant presenting to the emergency department with shock and poor responsiveness, found to have neonatal DM with hyperosmotic hyperglycemic syndrome (HHS). This report distinguishes NDM from T1DM, illustrating the subtle but clinically significant differences in pathophysiology and implications for initial management of NDM in the emergency department setting. |
| Databáze: | OpenAIRE |
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