Targeting of protein expression in renal disease using siRNA – A review

Autor:	Manal Ali Buabeid, Muhammad Umar, Zelal Jaber Kharaba, Ghulam Murtaza, Nihal Abdalla Ibrahim
Rok vydání:	2020
Předmět:	Signal Pathways business.industry Pharmaceutical Science RNA Disease medicine.disease Bioinformatics Genome Protein expression Review article medicine Pharmacology (medical) Identification (biology) business Kidney disease
Zdroj:	Tropical Journal of Pharmaceutical Research. 19:1313-1320
ISSN:	1596-9827 1596-5996
Popis:	The kidneys have rarely been used as a target in the systemic delivery of siRNA when compared to other tissues or organs in the body. This review article deals with various modalities adopted to deliver siRNA to the renal system under different normal and pathophysiological states. In this article, the authors have reviewed extensive clinical data that describe the use of siRNA for the treatment of renal diseases. Conventional and 3D modeling utilizes the existing genome-based RNA libraries, which facilitated the identification of molecular pathways involved in renal diseases. Keywords: siRNA, kidney disease, targeting proteins, signal pathways
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8d3bbe95f89ebf8a8e86969fbec7089f https://doi.org/10.4314/tjpr.v19i6.28 Zobrazit plný text záznamu Plný text ve formátu PDF