Abstract 6199: Bone microenvironment-suppressed T cells increase osteoclast formation and breast cancer bone metastases
| Autor: | Andrea Verdugo-Meza, Danna L. Arellano, Samanta Jiménez, Patricia Juárez, Pierrick G.J. Fournier, Juan A. Corral-Avila, Felipe Olvera-Rodriguez, Florian Drescher |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Cancer Research. 80:6199-6199 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/1538-7445.am2020-6199 |
| Popis: | Bone metastases are a frequent complication in patients with advanced breast cancer and remain incurable. Thus, we need to explore new options for their treatment. Immunotherapy for the treatment of cancer is promising but remains untested for bone metastases. A potential limitation for such use is the ability of T cells to activate osteoclasts and bone resorption that releases pro-metastatic growth factors. Thus, we aim to characterize the effect of T cells in bone metastases. When inoculated in Balb/C SCID mice that lack T and B cells or in T cell-depleted Balb/C mice, 4T1 cells caused 72% and 38% less bone metastases, respectively (p70% of T cells were PD-1+, and ~80% of monocytic-MDSC were PD-L1+, which could trigger T cell suppression in bone. In conclusion, we found that the bone metastasis microenvironment suppresses T cells, making them pro-osteoclastic and increases the development of bone metastases. We also found that activation of T cells prevented the formation of osteoclasts. Therefore, the activation of T cells using immunotherapy, such as immune checkpoint inhibitors (anti-PD-1 or anti-PD-L1 antibodies), could be used for the treatment of patients with bone metastases. Citation Format: Danna L. Arellano, Juan A. Corral-Avila, Florian Drescher, Andrea Verdugo-Meza, Samanta Jimenez, Felipe Olvera-Rodriguez, Patricia Juarez, Pierrick Fournier. Bone microenvironment-suppressed T cells increase osteoclast formation and breast cancer bone metastases [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 6199. |
| Databáze: | OpenAIRE |
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