Thermoresponsive, Hydrolytically Degradable Polymer Micelles Intended for Radionuclide Delivery
| Autor: | Göran Karlsson, Karel Ulbrich, Jan Kučka, Miroslav Vetrik, Sergey K. Filippov, David Vetvicka, Cestmir Konak, Hana Macková, Martin Hruby, Blanka Rihova, Katarina Edwards |
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| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
Hydrodynamic radius Polymers and Plastics Glycopolymer Bioengineering Polymer Micelle Biomaterials chemistry.chemical_compound chemistry Dynamic light scattering Polymer chemistry Materials Chemistry Copolymer Methacrylamide Thermoresponsive polymers in chromatography Biotechnology |
| Zdroj: | Macromolecular Bioscience. 9:1016-1027 |
| ISSN: | 1616-5187 |
| DOI: | 10.1002/mabi.200900083 |
| Popis: | Novel polymer micelles, prepared by self-assembling thermoresponsive poly(N-isopropylacrylamide)-graft-poly[N-(2-hydroxypropyl)methacrylamide] copolymers with hydrolytically degradable N-glycosylamine groups between the polymer blocks are proposed for delivery of diagnostic and therapeutic radionuclides into solid tumors. The micelles are formed by fast heating of an aqueous solution of the copolymer to 37 degrees C. They have a hydrodynamic diameter of 128 nm (measured using dynamic light scattering) and slowly degrade during incubation in aqueous buffer at pH = 7.4. Labeling with both (131)I and (90)Y proceeds with high yields (>85%). The unlabeled polymers are not cytotoxic for any of the tested murine and human cell lines. |
| Databáze: | OpenAIRE |
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