Molecular Markers of Gliomas
| Autor: | O. I. Kit, S. B. Panina, E. M. Frantsiyants, E. E. Rostorguev, D. I. Vodolazhsky |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Regulation of gene expression IDH1 Signal Pathways Pilocytic Astrocytomas Biology medicine.disease Microbiology Molecular medicine World health nervous system diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Infectious Diseases Virology Glioma Genetics medicine Cancer research neoplasms Molecular Biology 030217 neurology & neurosurgery Glioblastoma |
| Zdroj: | Molecular Genetics, Microbiology and Virology. 32:180-190 |
| ISSN: | 1934-841X 0891-4168 |
| DOI: | 10.3103/s0891416817040036 |
| Popis: | Gliomas are invasive recurrent brain tumors with high lethality. Gliomas have been morphologically divided into astrocytomas, oligodendrogliomas, and mixed oligoastrocytomas. Gliomas are graded according to the criteria of the World Health Organization criteria as grade I (pilocytic astrocytomas), grade II (low-grade gliomas), grade III (high-grade gliomas), and grade IV (glioblastoma). The mutations of IDH1/2 and TP53 genes and MGMT methylation have been described as prognostic markers of glioma. The aim of the present review is to analyze research and experimental results (Scopus, Web of Science, Pubmed) concerning somatic mutations, aberrant regulation of gene expression of signal pathways, diagnostic and prognostic markers of glioma progression and characterizing various morphological types and grades of glioma. In particular, the specificities of medulloblastomas and ependymomas have been considered in the present review. |
| Databáze: | OpenAIRE |
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