BEHAVIORAL FEATURES OF GALLIUM-68 RADIONUCLIDE INCORPORATED IN GLUCOSE DERIVATIVES IN LABORATORY ANIMALS

Autor:	O. V. Fedorov, V. K. Tishchenko, E. D. Stepchenkova, A. A. Fronya, V. M. Petriev
Rok vydání:	2020
Předmět:	010302 applied physics 010309 optics High rate Radionuclide Pharmacokinetics chemistry 0103 physical sciences food and beverages chemistry.chemical_element Gallium Pharmacology 01 natural sciences Electronic Optical and Magnetic Materials
Zdroj:	Bulletin of the Lebedev Physics Institute. 47:339-344
ISSN:	1934-838X 1068-3356
Popis:	This work is devoted to a comparative study of pharmacokinetic properties of complex compounds labeled with gallium-68 aminoglucose (68Ga-NODA-AG) or thioglucose (68Ga-NODA-TG) in BALB/c mice after intravenous administration. Statistical significance of activity accumulation in most organs and tissues was observed only at 5 min post-injection. At the following terms, these values didn’t have any statistical significance in most organs and tissues. Activity was eliminated from organs and tissues with high rate. The biological and effective half-lives of 68Ga-NODA-AG and 68Ga-NODA-TG from organs and tissues were less than 1 hour.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8d007f9817a054743657919ee5864d1b https://doi.org/10.3103/s1068335620110081 Zobrazit plný text záznamu Full text from SpringerLink