Patient-specific in vivo right ventricle material parameter estimation for patients with tetralogy of Fallot using MRI-based models with different zero-load diastole and systole morphologies
| Autor: | Pedro J. del Nido, Xueying Huang, Tal Geva, Zheyang Wu, Kristen L. Billiar, Han Yu, Dalin Tang, Alexander Tang, Chun Yang, Rahul H. Rathod |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Ejection fraction Receiver operating characteristic business.industry Estimation theory Diastole 030204 cardiovascular system & hematology medicine.disease 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Ventricle In vivo Internal medicine medicine Cardiology 030212 general & internal medicine Systole Cardiology and Cardiovascular Medicine business Tetralogy of Fallot |
| Zdroj: | International Journal of Cardiology. 276:93-99 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2018.09.030 |
| Popis: | Patient-specific in vivo ventricle material parameter determination is important for cardiovascular investigations. A new cardiac magnetic image (CMR)-based modeling approach with different zero-load diastole and systole geometries was adopted to estimate right ventricle material parameter values for healthy and patients with Tetralogy of Fallot (TOF) and seeking potential clinical applications. CMR data were obtained from 6 healthy volunteers and 16 TOF patients with consent obtained. CMR-based RV/LV models were constructed using two zero-load geometries (diastole and systole, 2G model). Material parameter values for begin-filling (BF), end-filling (EF), begin-ejection (BE), and end-ejection (EE) were recorded for analyses. Effective Young's moduli (YM) for fiber direction stress-strain curves were calculated for easy comparisons. The mean EE YM value of TOF patients was 78.6% higher than that of the healthy group (HG). The mean end-ejection YM value from worse-outcome TOF group (WG) post pulmonary valve replacement (PVR) surgery was 59.5% higher than that from the better-outcome TOF group (BG). Using begin-filling YM and end-ejection YM as predictors and the classic logistic regression model to different better-outcome group patients from worse-outcome group patients, the areas under Receiver Operating Characteristic (ROC) curves were found to be 0.797 and 0.883 for begin-filling YM and end-ejection YM, respectively. The sensitivity and specificity 0.761 and 0.755 using end-ejection YM as the predictor. This preliminary study suggests that ventricle material stiffness could be a potential parameter to be used to differentiate BG patients from WG patients with further effort and large-scale patient data validations. |
| Databáze: | OpenAIRE |
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