Direct and indirect radical denitrations of intermediates in the synthesis of sorgolactone and its nuclear analogs+

Autor:	László Tőke, István Kádas, Joseph Cs. Jaszberenyi, Geza Arvai, K. Miklo
Rok vydání:	1996
Předmět:	chemistry.chemical_classification Ketone chemistry Radical Organic Chemistry Drug Discovery Michael reaction Nitro Organic chemistry Amine gas treating Biochemistry Sorgolactone
Zdroj:	Tetrahedron Letters. 37:3491-3494
ISSN:	0040-4039
DOI:	10.1016/0040-4039(96)00560-6
Popis:	Denitration of various important intermediates in the synthesis of sorgolactone and its analogs using radical chemistry on nitroketones or on the derived isocyanides is described. The nitro group is needed for the first step of the annellation process, the Michael addition of substituted nitroalkanes to cyclopentenones. Then it can be removed directly or after reduction to the amine or via the ketone obtained by the Nef-reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8cfc8dda3255ace496433f04e8eaf3be https://doi.org/10.1016/0040-4039(96)00560-6 Zobrazit plný text záznamu Full Text from ScienceDirect