Synthesis of 14C-labelled 6-hydroxy-5,7-dimethyl-2-(methylamino)-4-(3-pyridylmethyl)benzothiazole dihydrochloride (14C-E3040 dihydrochloride)
| Autor: | Numata Hirotoshi, Osamu Takenaka, Shigeki Hibi, Mannen Mishima, Yasushi Okamoto |
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| Rok vydání: | 1995 |
| Předmět: |
biology
Bicyclic molecule Thromboxane Stereochemistry Organic Chemistry Biochemistry Medicinal chemistry Analytical Chemistry chemistry.chemical_compound Thiourea chemistry Benzothiazole Enzyme inhibitor Drug Discovery biology.protein Radiology Nuclear Medicine and imaging Specific activity Thromboxane-A synthase Phenols Spectroscopy |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 36:445-447 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/jlcr.2580360507 |
| Popis: | 14 C-Labelled 6-hydroxy-5,7-dimethyl-2-(methylamino)-4-(3-pyridylmethyl)-benzothiazole dihydrochloride ( 14 C-E3040 dihydrochloride), required for a study of the pharmacokinetic profile of E3040, a novel dual inhibitor of 5-lipoxygenase and thromboxane A 2 synthetase, was synthesized in one step using [2- 14 C]-1-methyl-2-thiourea as the labelled starting material. 14 C-E3040 dihydrochloride with a specific activity of 58.0mCi/mmol was prepared in 60% chemical yield(based on thiourea 2) |
| Databáze: | OpenAIRE |
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