Recent developments in human papillomavirus diagnosis and therapy in genital neoplasia

Autor: Peter L Stern
Rok vydání: 2002
Předmět:
Zdroj: Expert Opinion on Therapeutic Patents. 12:169-179
ISSN: 1744-7674
1354-3776
DOI: 10.1517/13543776.12.2.169
Popis: Infection with certain types of human papillomavirus (HPV) is casually associated with the development of cervical cancer and other anogenital neoplasia. There is increasing evidence of a wider association with other epithelial cancers. The availability of recombinant molecular biological techniques has circumvented the difficulties in studying the virus life cycle that is critically dependent on the differentiation of the epithelial target cell. From an understanding of the virology and cell biology of HPV infection, prospects for diagnostic and screening procedures in cervical neoplasia are being tested. The prize is the cost effective estimation of risk from HPV infection. New approaches need to be compared to existing and proven, although not perfect, smear test screening methods for prevention of cervical cancer. Novel research and development activities aimed at treating HPV infections in early premalignant lesions are utilising aspects of interference with early viral gene expression, or their co-o...
Databáze: OpenAIRE