Klinische Erfahrungen mit dem neuen Antiarrhythmikum Aprindin anhand von Langzeit-Trendanalysen

Autor:	H H Hilger, M D Freyland, D Steffel
Rok vydání:	1975
Předmět:	Drug medicine.diagnostic_test Aprindine business.industry Maintenance dose media_common.quotation_subject Renal function General Medicine medicine.disease Anesthesia Ambulatory medicine Anti arrhythmic business Electrocardiography Basal ganglia disease media_common medicine.drug
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 100:1764-1767
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-0028-1106457
Popis:	The therapeutic effectiveness of aprindine (Amidonal) was evaluated by trend analyses in 25 patients with predominantly severe forms of ventricular extrasystoles. The arrhythmia was stopped or improved in most instances. Severe side-effects for which the drug had to be discontinued occurred in three patients. The drug has a long half-life (about 20-30 hours). As a result, there can be cumulative dose-dependent side-effects, largely of a CNS type, disappearing after the dose has been reduced. Thirteen patients continued to be treated on an ambulatory basis, the oral maintenance dose averaging 100 mg/d, the mean follow-up period 11 1/2 months. There was no evidence of side-effects on liver, electrolytes, renal function or blood.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8cd757d627e903f1c3d56673f6c4960e https://doi.org/10.1055/s-0028-1106457 Zobrazit plný text záznamu