Effects of cytokine-like polypeptide EMAP II and flutamide on the testosterone-stimulated prostate of castrated rats
| Autor: | L I Poliakova, Reznikov Oh, Sachyns'ka Ov, Chaĭkovs'ka Lv |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Testosterone propionate
medicine.medical_specialty Physiology medicine.drug_class medicine.medical_treatment Antiandrogen medicine.disease Flutamide chemistry.chemical_compound Prostate cancer medicine.anatomical_structure Endocrinology Cytokine chemistry Prostate Apoptosis Internal medicine medicine Testosterone |
| Zdroj: | Fiziolohichnyĭ zhurnal. 57:12-20 |
| ISSN: | 2522-9036 2522-9028 |
| Popis: | The effects of separate and combined administration of cytokine-like polypeptide EMAP II and flutamide, a nonsteroid antiandrogen, on morphology and function of the accessory sexual glands in castrated rats stimulated with testosterone propionate were studied. We found antiangiogenic, procoagulating and proapoptotic effects of EMAP II in the ventral prostate. Combined administration of the preparations enhanced their antiprostatic effects, which were manifested in inhibition of the androgen-dependent processes in prostate tissues, changes in proliferation and apoptosis, DNA, RNA and protein contents. We conclude that combined administration of EMAP II and flutamide can be used for development of new therapeutic modalities in prostate cancer. |
| Databáze: | OpenAIRE |
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