N-Substituted benzoxazolyl ureas and thioureas in Biginelli reaction promoted by trifluoromethane sulfonic acid: An efficient and convenient synthesis of substituted benzoxazolyl 3,4-dihydropyrimidine (1H)-(thio)-ones

Autor:	K. Srinivas, M. Saranga Pani, M. Arjun, T. Raviprasad, D. Sridhar
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Semicarbazides Chemistry Biginelli reaction Thio Organic chemistry General Chemistry Sulfonic acid Medicinal chemistry Catalysis
Zdroj:	Chinese Chemical Letters. 20:909-912
ISSN:	1001-8417
DOI:	10.1016/j.cclet.2009.04.010
Popis:	An efficient synthesis of 3,4-dihydropyrimidine 2 (1 H )-ones and thiones (3,4-DHPMs) core was prepared by one-pot three-component Biginelli condensation and which was catalyzed by trifluoromethane sulfonic acid. The classical Bignelli reaction has been extended by the use of N-substituted benzoxazolyl semicarbazides and thiosemicarbazides and this method has the advantage of excellent yields and short reaction times.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8cb89ba52ee355d05207988dc8a8ebe4 https://doi.org/10.1016/j.cclet.2009.04.010 Zobrazit plný text záznamu Full Text from ScienceDirect