Effect of thyrotrophin releasing hormone on secretion of thyrothrophic hormone and prolactin in a monolayer culture of rat adenohypophysis
| Autor: | V. P. Fedotov, Rappay G, I. S. Komolov, L. G. Morozova, M. Fecete, I. Fazekas |
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| Rok vydání: | 1978 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Chemistry Cell Thyroid General Medicine General Biochemistry Genetics and Molecular Biology Prolactin medicine.anatomical_structure Endocrinology Hormone receptor Cytoplasm Internal medicine medicine Liberation Secretion hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 85:218-220 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00800132 |
| Popis: | Cells of the adenophypophysis in a primary 5–8-day monolayer culture react to addition of thyrotrophin releasing hormone (TRH) by rapid dose-dependent liberation of thyrotrophic hormone (TSH) and prolactin into the culture medium. This effect is independent of the content of serum in the nutrient medium. The thyroid hormone thyroxin blocks the stimulating action of TRH on the secretion of TSH, but not of prolactin. The blocking effect of thyroxin is evidently manifested not on cell membranes, but in the cytoplasm distally to the effect of cyclic AMP, along the pathway of transmission of the hormonal signal. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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