Pd-Catalyzed Regioselective Mono-Arylation: Quinazolinone as the Inherent Directing Group for C(sp2)–H Activation

Autor:	Dnyaneshwar N. Garad, Amol B. Viveki, Santosh B. Mhaske
Rok vydání:	2017
Předmět:	010405 organic chemistry Stereochemistry Organic Chemistry Substrate (chemistry) Regioselectivity Aromaticity 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Quinazolinone
Zdroj:	The Journal of Organic Chemistry. 82:6366-6372
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.7b00948
Popis:	The Pd-catalyzed quinazolinone-directed regioselective monoarylation of aromatic rings by C–H bond activation is developed. A broad substrate scope is demonstrated for both quinazolinone as well as diaryliodonium triflates. The use of a base was found to be crucial for this transformation, unlike for the known nitrogen-directed arylations. All of the novel quinazolinones of biological interest were synthesized by using the operationally simple Pd(II)-catalyzed arylation reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8ca08200dc42c82d85d0642cd43abad1 https://doi.org/10.1021/acs.joc.7b00948 Zobrazit plný text záznamu