Efficient Synthesis of Chiral Isoquinoline and Pyrido[1,2-b]-isoquinoline Derivatives via Intramolecular Heck Reactions

Autor:	Enrique Mann, Francisco Sánchez-Sancho, Bernardo Herradón
Rok vydání:	2001
Předmět:	chemistry.chemical_compound chemistry Heck reaction Intramolecular force Organic Chemistry Substituent chemistry.chemical_element Substrate (chemistry) Isoquinoline Medicinal chemistry Catalysis Palladium
Zdroj:	Advanced Synthesis & Catalysis. 343:360-368
ISSN:	1615-4169 1615-4150
DOI:	10.1002/1615-4169(20010430)343:4<360::aid-adsc360>3.0.co;2-2
Popis:	The palladium(0)-catalyzed reaction of derivatives of γ-amino-α,β-unsaturated esters bearing an N-(2-iodobenzoyl) substituent results in an intramolecular Heck reaction, the outcome of which depends on the structure of the substrate as well as on the experimental conditions. The methodology developed has been applied to the efficient syntheses of chiral isoquinoline and pyrido[1,2-b]–isoquinoline derivatives.
Databáze:	OpenAIRE
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