The Roles And Signaling Pathways Of Phosphatidylethanolamine-Binding Protein 4 In Tumors

Autor:	Xiaoqin Qu, Zi-Kang Luo, Xiao-Yan Zhou, Qiong-Feng Chen
Rok vydání:	2019
Předmět:	0301 basic medicine Chemotherapy medicine.medical_treatment Therapeutic resistance Biology medicine.disease Metastasis Targeted therapy Radiation therapy 03 medical and health sciences Phosphatidylethanolamine Binding Protein 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Cancer cell medicine Cancer research Pharmacology (medical) Signal transduction
Zdroj:	OncoTargets and Therapy. 12:7685-7690
ISSN:	1178-6930
DOI:	10.2147/ott.s216161
Popis:	Phosphatidylethanolamine-binding protein 4 (PEBP4) has been found to be highly expressed in many tumors and to be closely related to the proliferation, differentiation, and metastasis of tumors. PEBP4 has also been found to be involved in many cancer-activated signaling pathways and to cause therapeutic resistance. In this study, we first reviewed the morphological structure and expression of PEBP4, then discussed the roles of PEBP4 in individualized treatment of some cancers, and finally explored the possibilities of cultivating PEBP4 as a therapeutic target.We also identified the main signaling pathways in which PEBP4 affects different cancers. It is here concluded that over-expression of PEBP4 can enhance the proliferation and metastasis of the cancer cells and the resistance to radiotherapy/chemotherapy in cancers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8c9f0f6469ce6a74673617708fbf6e28 https://doi.org/10.2147/ott.s216161 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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