Can high doses of inhaled corticosteroids increase the level of total serum cholesterol?: a retrospective cohort study
| Autor: | Ana Sánchez Azofra, Maria Teresa Pastor, Adrián Martínez Vergara, Julio Ancochea Bermúdez, Beatriz Aldave Orzaiz, Carmen María Acosta Gutiérrez, Ana Roca Noval, Ana Martínez Meca, Elena Avalos Perez-Urria, Marta Erro Iribarren, Joan B. Soriano, Carolina Cisneros Serrano |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Cholesterol business.industry medicine.drug_class Inhaled corticosteroids Retrospective cohort study medicine.disease Gastroenterology Fluticasone propionate chemistry.chemical_compound chemistry Internal medicine Medicine Corticosteroid lipids (amino acids peptides and proteins) business Body mass index medicine.drug Fluticasone Asthma |
| Zdroj: | Airway pharmacology and treatment. |
| DOI: | 10.1183/13993003.congress-2019.pa2555 |
| Popis: | Introduction: A recent meta-analysis concluded that adults with asthma have higher LDL-cholesterol levels than healthy controls. Some studies relate this increase with the inhaled corticosteroid dose. In clinical practice we frequently observe high cholesterol levels in our patients with severe asthma. The objective of this study was to evaluate the levels of total cholesterol in patients receiving treatment with high inhaled corticosteroids dose (HICD). Methods: Patients followed-up in a severe asthma unit were included in this retrospective cohort study. Patients on long-term systemic corticosteroids (SC) treatment were excluded, and doses of SC were collected in those who used short bursts during exacerbations. Given that only 35% of our patients had collected the LDL-cholesterol and HDL-cholesterol values, we could not include them in the analysis. Results: We included 70 patients, 81% women, with a mean age of 56 ± 16 years. The mean body mass index (BMI) was 28.62 ± 5.63. The average diagnose age was 30’7 years. 95’7% received fluticasone, while 4’3% beclomethasone, being the average dose (equivalent of fluticasone propionate) of 1024’29 ± 159 mcg. The mean value of total cholesterol was 213’79 ± 33’48 (70% of patients present cholesterol ≥ 200 and 21% of them ≥ 240). We found a statistically significant relationship between BMI and cholesterol levels. Conclusions: 70% of our patients had total cholesterol ≥200 mg / dL, 21% being ≥240 mg / dL. Patients with higher BMI had total cholesterol > 200 mg / dL. More studies should be carried out to clarify the possible relationship between the HICD treatment and the increase in total cholesterol levels. |
| Databáze: | OpenAIRE |
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