Effects of Chemical Compounds upon Current Induced Thrombosis in Rat Mesenteric Vessels

Autor:	Burrowes Cb, Srinivasan S, Sawyer Pn, Aaron Rk
Rok vydání:	1970
Předmět:	Pathology medicine.medical_specialty business.industry Hematology Heparin Ethylmaleimide medicine.disease Thrombosis Mesenteric Vein Appendix Surgery chemistry.chemical_compound medicine.anatomical_structure Podophyllin chemistry medicine Chondroitin business Mesenteric arteries medicine.drug
Zdroj:	Thrombosis and Haemostasis. 23:621-626
ISSN:	2567-689X 0340-6245
DOI:	10.1055/s-0038-1654192
Popis:	SummaryFrom previous work in our laboratories, there is a large amount of evidence for an electrochemical mechanism of thrombosis. The blood vessel wall and blood cells are negatively charged under normal conditions. Antithrombogenic drugs increase their negative charge densities while thrombogenic drugs have the opposite effect. Injury makes the blood vessel wall less negatively charged or even positively charged. There is a relation between vascular injury currents and thrombosis. In the present study, the effect of certain chemical agents upon in situ thrombosis in rat mesoappendix vessels, produced by an applied electric current of the sign and magnitude of physiological injury currents, is examined. Compounds such as polyquarternary, with basic groups enhance thrombosis while compounds such as heparin with acidic groups inhibit thrombosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8c9922c12151f2b9abb439fe86445da8 https://doi.org/10.1055/s-0038-1654192 Zobrazit plný text záznamu