Serum Antibodies Reactive with Saccharomyces cerevisiae in Inflammatory Bowel Disease: Is IgA Antibody a Marker for Crohn’s Disease?

Autor:	C.H. Taylor-Robinson, Susan Allan, R.M.R. Barnes, Ronald Finn, Peter M. Johnson
Rok vydání:	1990
Předmět:	Crohn's disease medicine.diagnostic_test Immunology Anti–Saccharomyces cerevisiae antibody General Medicine Biology Immunoglobulin E medicine.disease Ulcerative colitis Inflammatory bowel disease Antigen Immunoassay medicine biology.protein Immunology and Allergy Antibody
Zdroj:	International Archives of Allergy and Immunology. 92:9-15
ISSN:	1423-0097 1018-2438
DOI:	10.1159/000235217
Popis:	Sera from patients with Crohn’s disease (CD) and ulcerative colitis (UC) have been evaluated for antibodies reactive with Saccharomyces cerevisiae (anti-Sacc antibodies) using an enzyme-linked immunoassay (ELISA). IgG anti-Sacc antibodies were detected in 63% (25/40) of CD patients, compared with 15% (4/27) of UC patients (p Escherichia coli antibodies was not significantly different between CD (75%) or UC (79%) patients. More particularly, elevated levels of serum IgA anti-Sacc antibodies were detected in 17/40 CD patients, but in none of the 27 UC patients. These data confirm that serum antibodies reactive with S. cerevisiae are strongly associated with CD and further show that serum IgA anti-Sacc antibodies may be specific for this disorder.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8c8a2271e7fee9f4489c8bbc6f040178 https://doi.org/10.1159/000235217 Zobrazit plný text záznamu