Superparamagnetic nanopreparations in early diagnostics and treatment of cancer

Autor:	V.A. Polyanskiy, N. A. Brusentsov, Yu M. Bukreyev, M. V. Gulyayev, A. E. Barmashov, Yu A. Pirogov, O. A. Bocharova, I.S. Golubeva, N.V. Anisimov, M. A. Baryshnikova
Rok vydání:	2019
Předmět:	History business.industry medicine Cancer research Cancer medicine.disease business Computer Science Applications Education
Zdroj:	Journal of Physics: Conference Series. 1389:012071
ISSN:	1742-6596 1742-6588
Popis:	The superparamagnetic nanoparticles of magnetite citrate (SNMCs) consisting of nanospheres aggregates with the hydrodynamic diameter being between 15 to 35 nm with a magnetite core diameter of 3 to 12 nm, coated with of citrate anions was synthesized. A water 2-5% sol of SNMC was successfully tested as magnetic resonance imaging (MRI) contrast agent. The same 40% sol was then combined with Inox and used at regional magneto-thermo-chemo-therapy (RMTCT) of Lewis lung carcinoma (LLC) and Ehrlich carcinoma (EC), in female C57Bl / 6j mice. In the early stages of carcinoma development, the proliferation centers of LLC and EC cells were visualized and, during treatment, they obtained a significant increase in the efficiency of regional magneto-thermo-chemo-therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8c83938aafa71453fdfc4e95f8dbe5ca https://doi.org/10.1088/1742-6596/1389/1/012071 Zobrazit plný text záznamu