Preclinical Investigation of the Safety of Eplir

Autor:	Livshits Ns, R. R. Akhmedzhanov, Kadychagova Ng, T. V. Perevozchikova, Bashirova Lv, T. P. Novozheeva, A. S. Saratikov, Burchenkova Fi
Rok vydání:	2005
Předmět:	Pharmacology Drug Reproductive function business.industry Chemistry media_common.quotation_subject Pharmacology toxicology Pharmacy Acute toxicity Drug Discovery business Carcinogen media_common
Zdroj:	Pharmaceutical Chemistry Journal. 39:64-66
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-005-0082-3
Popis:	The preclinical toxicological evaluation of eplir, a new hepatoprotective drug, has been performed. It was established that, in terms of the acute toxicity parameters, eplir is a low-toxicity substance. A six-month peroral administration of the drug in a dose of 30, 150, and 300 mg/kg in rats and 100 mg/kg in dogs did not cause any substantial functional and structural disorders in the organs and systems of the experimental animals. Eplir does not possess mutagenic, carcinogenic, allergenic, and immunotoxic properties and does not affect the reproductive function.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8c817712f7aa2977240424a2ca7d5df7 https://doi.org/10.1007/s11094-005-0082-3 Zobrazit plný text záznamu Plný text ve formátu PDF