Thromboxane Receptor Blockade Causes Acidemia in the Ovine Fetus

Autor:	Jan E. Dickinson, Valerie M. Parisi, Bruce A. Meyer
Rok vydání:	1992
Předmět:	medicine.medical_specialty Fetus Mean arterial pressure business.industry Thromboxane Obstetrics and Gynecology Umbilical artery pCO2 Thromboxane receptor Endocrinology medicine.artery Internal medicine Pediatrics Perinatology and Child Health Arterial blood Medicine Base excess business
Zdroj:	Journal of Maternal-Fetal and Neonatal Medicine. 1:167-171
ISSN:	1476-4954 1476-7058
DOI:	10.3109/14767059209161912
Popis:	The placenta produces the vasoactive eicosanoids thromboxane and prostacyclin. We hypothesized that fetal administration of SQ 29,548, a thromboxane receptor blocker, would lack direct cardiorespiratory effects in the ovine fetus. Continuous monitoring of maternal and fetal heart rates, blood pressures, and common umbilical artery blood flow was performed in six chronically catheterized pregnant ewes. Serial maternal and fetal arterial blood gases and serum lactates were obtained. After 120 minutes of infusion, a significant decrease in fetal mean arterial pressure and a significant increase in fetal heart rate was observed. A significant decrease in fetal arterial pH (7.41 ± 0.02 to 7.33 ± 0.02), PO2 (26.8 ± 3.2 to 19.8 ± 3.4), HCO3− (27.2 ± 1.5 to 24.9 ± 2.0), and base excess (2.9 ± 1.6 to 0.2 ± 2.3) with a significant elevation in PCO2 (45.4 ± 2.6 to 50.1 ± 3.3) occurred after 120 minutes of SQ 29,548 infusion. SQ 29,548 infusion caused a significant decrease in common umbilical artery flow, from 249.4...
Databáze:	OpenAIRE
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