Drug-Lipid Interactions in the Model Membrane, Dppc-Water: A DSC and Proton NMR Study

Autor:	K. U. Deniz, Lata Panicker, P. S. Parvathanathan, CL Khetrapal, Geeta Datta, K. V. Ramanathan, Subramanian Vivekanandan
Rok vydání:	1996
Předmět:	Drug Stereochemistry media_common.quotation_subject Condensed Matter Physics Medicinal chemistry Paraben chemistry.chemical_compound Membrane chemistry Proton NMR Molecule Salicylic acid Vicinal PROPYL PARABEN media_common
Zdroj:	Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals. 288:237-247
ISSN:	1058-725X
DOI:	10.1080/10587259608034600
Popis:	The interactions of the keratolytic drug Salicylic Acid (SA) and the antifungal drugs Methyl Paraben (MPB) and Propyl Paraben (PPB) with the model membrane, DPPC-Water, have been studied using DSC and H-1 NMR. The results show that these drug molecules are situated near the membrane interface with their polar group(s) interacting with the vicinal water, while the aromatic regions and the methyl and propyl groups of MPB and PPB interact with the neighbouring hydrophobic regions of the DPPC molecule. The strength of interaction of the aromatic group is in the order PPB > MPB > SA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8c7ec159f78a8297e1ddd012ca280c8c https://doi.org/10.1080/10587259608034600