Novel carboxylic acid terminated silicon(IV) and zinc(II) phthalocyanine photosensitizers: Synthesis, photophysical and photochemical studies
| Autor: | Göknur Yaşa Atmaca, Gülşah Gümrükçü Köse, Arif Hışır, Gülnur Keser Karaoğlan, Ali Erdoğmuş |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Silicon 010405 organic chemistry Carboxylic acid medicine.medical_treatment chemistry.chemical_element Photodynamic therapy General Chemistry Zinc Conjugated system 010402 general chemistry Photochemistry 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry medicine Phthalocyanine |
| Zdroj: | Journal of Porphyrins and Phthalocyanines. 22:1010-1021 |
| ISSN: | 1099-1409 1088-4246 |
| Popis: | In order to improve the efficacy of photochemical properties for photodynamic therapy (PDT) applications, carboxylic acid groups axially conjugated with silicon(IV) and at the peripheral position with zinc(II) phthalocyanine skeletons for new photosensitizers to investigate the influence of the COOH group positions on the photophysicochemical performance are described in this study. Silicon (IV) (3 and 5) and zinc (II) (7) phthalocyanines were characterized by UV-vis, FTIR, 1H-NMR, MALDI-TOF MS and elemental analysis spectral data. Furthermore, the photophysical (fluorescence quantum yields and fluorescence quenching studies), photochemical (photodegradation and singlet oxygen generation) and aggregation properties of the newly synthesized phthalocyanines were investigated in dimethylformamide (DMF) and dimethyl sulfoxide (DMSO) solutions. The results were compared with that of zinc and silicon phthalocyanines. Singlet oxygen quantum yields ranged from 0.23 to 0.63 via Type II mechanism under the experimental conditions studied. The fluorescence of the phthalocyanine complexes (3, 5 and 7) is effectively quenched by 1,4-benzoquinone (BQ) in DMSO, DMF and THF. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|