Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis
| Autor: | Alice M. R. Bernardino, Karen dos Santos Charret, Adriana V. Carvalho, Raquel Fonseca Rodrigues, Marilene M. Canto-Cavalheiro, Adriana O. Gomes, Veronica F. Amaral, Leonor L. Leon |
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| Rok vydání: | 2009 |
| Předmět: |
Kinetoplastida
Leishmaniasis Pyrazole Biology Carbohydrazide medicine.disease biology.organism_classification Microbiology chemistry.chemical_compound Infectious Diseases Visceral leishmaniasis chemistry Cutaneous leishmaniasis Virology parasitic diseases Toxicity Immunology medicine Parasitology Lymph |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 80:568-573 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.2009.80.568 |
| Popis: | Newly synthesized pyrazole carbohydrazide derivatives with substituents X = Br/Y = NO 2 and X = NO 2 /Y = Cl were independently investigated in the CBA mouse model of cutaneous leishmaniasis. Animals were infected with Leishmania amazonensis and treated two weeks after the parasitic infection with the pyrazole carbohy- drazides for 45 days. Oral treatment with both compounds controlled evolution of footpad cutaneous lesions and dissemination of parasites to draining lymph nodes. Nitric oxide generation was observed in supernatants of lymph node cells from infected CBA mice that were treated with these compounds. The pyrazole carbohydrazide derivatives did not show any toxicity or cause alterations in body weight, plasma concentrations of alanine aminotransferase and aspar- tate aminotransferase, and urinary creatinine levels, but promoted a small decrease in blood neutrophils. These results provide new perspectives on the development of drugs with activities against leishmaniasis. 1 It is caused by protozoans of the genus Leishmania and the bite of phleboto- mine sand flies. In Brazil, Leishmania amazonensis is responsi- ble for most cases reported, which include cutaneous, mucosal, diffuse cutaneous, and visceral leishmaniasis, and is considered a species of epidemiologic importance. 2-4 |
| Databáze: | OpenAIRE |
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