Effects of IM28 on HIV-1 and Metabolic Disorders-induced Highly Active Antiretroviral Therapy in Gabonese Patients
| Autor: | Virginie Mavoungou-Poaty, Maka Gontran, Mavoungou Elie, Akoume Marie Yvonne, Ongali Brice, Loundou Tsoumbou Jerome, Mavoungou Donatien |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
business.industry media_common.quotation_subject virus diseases Dehydroepiandrosterone Appetite Pharmacology medicine.disease Omics Gastroenterology Infectious Diseases Blood pressure Insulin resistance Virology Internal medicine Medicine Distribution (pharmacology) business Viral load Hormone media_common |
| Zdroj: | Journal of Antivirals & Antiretrovirals. |
| ISSN: | 1948-5964 |
| DOI: | 10.4172/jaa.1000011 |
| Popis: | Highly active antiretroviral therapy (HAART) was recently associated with disturbance of lipid metabolism, fat mass distribution and insulin resistance, known to be partly regulated by steroid hormones. Nevertheless, complementary or adjunctive wide used of dehydroepiandrosterone (DHEA) in fully suppressed HIV patients appeared to have no beneficial antiviral, immuno modulatory, hormonal or body composition effects. Herein, we tested in vivo safety and efficacy of IM28, a potent analog of DHEA, on volunteers HIV positive patients from Gabon, randomly organized as followed: IM28 alone (15 patients + 30 healthy individuals), IM28+HAART (150 patients), HAART alone (13 patients) and DHEA+HAART (23 patients). All patients were evaluated three times: M0 (pre-treatment with IM28), M1 (after six months of treatment with IM28) and M2 (after 12 months of treatment with IM28). No noticeable side effects were observed for IM28 as evaluated by measuring hepatic, cardiac, renal functions and body weight progression. Compared to HAART therapy, combinations DHEA+HAART, IM28+HAART or IM28, quickly rescued patients from anxiety, restored their appetite and normalized their body weight. However, only patients receiving IM28 alone or in combination with HAART showed normalization of body temperatures and increase in the levels of CD4 lymphocytes (p |
| Databáze: | OpenAIRE |
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